Surface modification of biomaterials using plasma treatment can significantly affect the wettability and biocompatibility of the materials. Plasma treatment is a process that involves the use of ionized gas to modify the surface properties of a material without altering its bulk properties. This process can lead to several changes in the surface properties of biomaterials, including improved wettability and biocompatibility.1. Wettability: Plasma treatment can increase the wettability of biomaterials by introducing polar functional groups onto the surface. These functional groups can interact with water molecules, leading to an increase in surface energy and hydrophilicity. As a result, the treated biomaterials can better absorb water and other biological fluids, which is essential for various biomedical applications, such as drug delivery and tissue engineering.2. Biocompatibility: Plasma treatment can also enhance the biocompatibility of biomaterials by altering their surface chemistry and topography. The introduction of functional groups, such as hydroxyl, carboxyl, and amine groups, can promote cell adhesion, proliferation, and differentiation. These functional groups can also reduce the risk of immune responses and inflammation, which are common issues associated with the use of biomaterials in medical applications.Moreover, plasma treatment can create nanoscale surface roughness, which has been shown to promote cell adhesion and growth. This surface roughness can mimic the natural extracellular matrix, providing a more favorable environment for cell attachment and tissue integration.In summary, plasma treatment can significantly improve the wettability and biocompatibility of biomaterials by introducing functional groups and altering surface topography. These modifications can enhance the performance of biomaterials in various biomedical applications, such as drug delivery, tissue engineering, and implantable devices.