Glycolysis and gluconeogenesis are two metabolic pathways that play crucial roles in energy metabolism. Glycolysis is the process of breaking down glucose into pyruvate, while gluconeogenesis is the process of synthesizing glucose from non-carbohydrate precursors.In glycolysis, the net yield of ATP is 2 molecules per molecule of glucose. This is because 2 ATP molecules are consumed in the initial steps of glycolysis, and 4 ATP molecules are produced in the later steps, resulting in a net gain of 2 ATP molecules.Gluconeogenesis, on the other hand, is an energy-consuming process. It requires the input of 6 ATP molecules 4 ATP and 2 GTP to synthesize one molecule of glucose from non-carbohydrate precursors such as pyruvate, lactate, or certain amino acids. The difference between these two processes lies in their roles and energy requirements. Glycolysis is a catabolic pathway that generates ATP by breaking down glucose, while gluconeogenesis is an anabolic pathway that consumes ATP to synthesize glucose. The net yield of ATP in glycolysis is positive 2 ATP molecules , while in gluconeogenesis, there is no net production of ATP, as it is an energy-consuming process.