Glycolysis and gluconeogenesis are two metabolic pathways that occur in cells. Glycolysis is the process of breaking down glucose into two molecules of pyruvate, while gluconeogenesis is the process of synthesizing glucose from non-carbohydrate precursors, such as pyruvate, lactate, glycerol, and certain amino acids.In glycolysis, the net energy yield is 2 ATP molecules per glucose molecule. This is because 2 ATP molecules are consumed in the initial steps of glycolysis, and 4 ATP molecules are produced in the later steps, resulting in a net gain of 2 ATP molecules.Gluconeogenesis, on the other hand, is an energy-consuming process. To synthesize one molecule of glucose, 6 ATP molecules are consumed 4 ATP and 2 GTP molecules . Therefore, the net energy yield of gluconeogenesis is -6 ATP molecules per glucose molecule synthesized.The difference in the net energy yield between glycolysis and gluconeogenesis is 8 ATP molecules 2 ATP from glycolysis minus -6 ATP from gluconeogenesis . This difference reflects the fact that glycolysis is an energy-producing pathway, while gluconeogenesis is an energy-consuming pathway.