The stability and porosity of coordination polymers or metal-organic frameworks MOFs can be systematically tuned and controlled for targeted applications in drug delivery or gas storage by manipulating their structural properties and chemical compositions. Here are some strategies to achieve this:1. Choice of metal ions: The selection of appropriate metal ions can influence the stability and porosity of MOFs. Metal ions with higher coordination numbers and larger ionic radii can lead to more stable and porous structures.2. Choice of organic linkers: The choice of organic linkers can also significantly impact the stability and porosity of MOFs. By selecting linkers with different lengths, shapes, and functionalities, one can control the pore size, shape, and surface chemistry of the MOFs, which in turn affects their stability and gas storage or drug delivery capabilities.3. Functionalization of organic linkers: The introduction of functional groups on the organic linkers can enhance the stability and porosity of MOFs by providing additional binding sites for guest molecules or by promoting specific interactions with the target molecules.4. Post-synthetic modification: Post-synthetic modification techniques, such as solvent-assisted linker exchange SALE or post-synthetic metalation, can be employed to modify the structure and properties of MOFs after their synthesis. This allows for the fine-tuning of their stability, porosity, and functionality for specific applications.5. Control of synthesis conditions: The synthesis conditions, such as temperature, pressure, and solvent choice, can significantly affect the formation of MOFs with desired stability and porosity. By carefully controlling these parameters, one can obtain MOFs with optimal properties for targeted applications.6. Incorporation of secondary building units SBUs : The introduction of SBUs, which are small clusters of metal ions and organic linkers, can lead to the formation of hierarchical porous structures in MOFs. This can enhance their stability and porosity, making them suitable for drug delivery or gas storage applications.7. Mixed-metal or mixed-linker MOFs: The use of mixed-metal or mixed-linker MOFs can provide additional opportunities for tuning the stability and porosity of MOFs. By combining different metal ions or organic linkers, one can create MOFs with unique properties that are tailored for specific applications.8. Computational modeling: Computational modeling and simulation techniques can be employed to predict the stability and porosity of MOFs, as well as their interactions with guest molecules. This can help guide the design and synthesis of MOFs with desired properties for targeted applications.By employing these strategies, chemists can systematically tune and control the stability and porosity of coordination polymers or MOFs for targeted applications in drug delivery or gas storage.