Self-assembly is a process by which molecules spontaneously organize themselves into well-defined, stable structures through non-covalent interactions such as hydrogen bonding, van der Waals forces, hydrophobic interactions, and electrostatic interactions. Utilizing self-assembly to create supramolecular structures for drug delivery applications involves designing and synthesizing molecules that can spontaneously form the desired structures with specific properties tailored for efficient drug delivery.Here are some strategies to utilize self-assembly for creating supramolecular structures for drug delivery applications:1. Designing amphiphilic molecules: Amphiphilic molecules have both hydrophilic water-loving and hydrophobic water-hating parts. When placed in an aqueous environment, these molecules can self-assemble into various supramolecular structures, such as micelles, vesicles, or hydrogels. These structures can encapsulate hydrophobic drugs within their hydrophobic core, protecting them from degradation and enhancing their solubility in the body.2. Stimuli-responsive supramolecular structures: Designing supramolecular structures that respond to specific stimuli, such as pH, temperature, or the presence of certain enzymes, can enable targeted drug release at the desired site of action. For example, supramolecular hydrogels that disassemble at a specific pH can release their encapsulated drug payload in the acidic environment of a tumor.3. Incorporating targeting moieties: By incorporating specific targeting moieties, such as peptides or antibodies, into the supramolecular structure, it is possible to enhance the selective uptake of the drug-loaded structure by the target cells. This can improve the therapeutic efficacy of the drug and reduce side effects on healthy cells.4. Multifunctional supramolecular structures: Designing supramolecular structures that can carry multiple therapeutic agents, such as a combination of drugs or a drug and a diagnostic agent, can enable synergistic therapeutic effects and real-time monitoring of drug delivery.5. Biodegradable supramolecular structures: Designing supramolecular structures that can degrade into biocompatible byproducts after drug release can minimize the potential toxicity and long-term accumulation of the drug delivery system in the body.In summary, self-assembly can be utilized to create supramolecular structures with specific properties for drug delivery applications by designing and synthesizing molecules that can spontaneously form the desired structures. These structures can be tailored for efficient drug delivery by incorporating features such as amphiphilicity, stimuli-responsiveness, targeting moieties, multifunctionality, and biodegradability.