The self-assembly of supramolecular structures can be manipulated for the development of new and more efficient drug delivery systems by focusing on the following strategies:1. Selection of building blocks: The choice of appropriate building blocks is crucial for the formation of supramolecular structures. These building blocks can be small organic molecules, polymers, peptides, or even biomacromolecules like proteins and nucleic acids. By carefully selecting and designing these building blocks, one can control the size, shape, and functionality of the resulting supramolecular structures.2. Non-covalent interactions: Supramolecular structures are held together by non-covalent interactions such as hydrogen bonding, van der Waals forces, - stacking, and electrostatic interactions. By tuning these interactions, one can manipulate the stability, solubility, and responsiveness of the supramolecular structures, which in turn can affect their drug delivery capabilities.3. Stimuli-responsive behavior: Designing supramolecular structures that can respond to specific stimuli e.g., pH, temperature, light, or enzymes can enable controlled drug release at the target site. This can be achieved by incorporating stimuli-responsive moieties into the building blocks or by exploiting the inherent responsiveness of certain supramolecular structures.4. Encapsulation and release of drugs: The drug molecules can be encapsulated within the supramolecular structures through various methods, such as co-assembly, post-assembly encapsulation, or covalent conjugation. The release of the drug can be controlled by manipulating the stability and responsiveness of the supramolecular structures, as well as by designing structures with specific drug release mechanisms e.g., disassembly, diffusion, or degradation .5. Targeting and bioavailability: To improve the targeting and bioavailability of the drug-loaded supramolecular structures, one can incorporate targeting ligands, such as antibodies, peptides, or small molecules, that can specifically bind to receptors on the target cells. Additionally, modifying the surface properties of the supramolecular structures e.g., with hydrophilic or hydrophobic moieties can influence their circulation time, biodistribution, and cellular uptake.6. Biocompatibility and biodegradability: Ensuring the biocompatibility and biodegradability of the supramolecular structures is essential for their safe use in drug delivery applications. This can be achieved by using biocompatible and biodegradable building blocks, as well as by controlling the size and surface properties of the supramolecular structures.In summary, the self-assembly of supramolecular structures can be manipulated for the development of new and more efficient drug delivery systems by carefully selecting and designing the building blocks, tuning the non-covalent interactions, incorporating stimuli-responsive behavior, controlling the encapsulation and release of drugs, improving targeting and bioavailability, and ensuring biocompatibility and biodegradability.