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What is the appropriate reaction conditions, including the amount of benzyl chloride and ammonia, temperature, and time, needed to achieve the highest possible yield of phenylalanine in the synthesis from benzyl chloride and ammonia?

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To achieve the highest possible yield of phenylalanine from the reaction of benzyl chloride and ammonia, the following reaction conditions are recommended:1. Stoichiometry: Use a 1:1 molar ratio of benzyl chloride and ammonia. This ensures that both reactants are consumed completely, maximizing the yield of phenylalanine.2. Temperature: The reaction should be carried out at a temperature of around 0C. This helps to minimize side reactions and decomposition of the product.3. Time: The reaction should be allowed to proceed for at least 24 hours to ensure complete conversion of the reactants to the desired product.4. Solvent: Use a polar aprotic solvent, such as dimethylformamide  DMF  or dimethyl sulfoxide  DMSO , to dissolve both reactants and facilitate the reaction.5. Catalyst: Adding a phase-transfer catalyst, such as tetrabutylammonium bromide  TBAB , can help to increase the reaction rate and improve the yield of phenylalanine.6. Purification: After the reaction is complete, the product can be isolated and purified using standard techniques, such as extraction, crystallization, or chromatography.Please note that these conditions are general guidelines and may need to be optimized for your specific setup and reactants. Always consult the relevant literature and safety data sheets before performing any chemical reaction.
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