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What is the step-by-step mechanism for the synthesis of phenylalanine from benzyl chloride and ammonia?

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The synthesis of phenylalanine from benzyl chloride and ammonia can be achieved through a three-step process involving the formation of an intermediate compound, benzylamine. Here is the step-by-step mechanism:Step 1: Formation of Benzylamine1. Benzyl chloride  C6H5CH2Cl  reacts with ammonia  NH3  in a nucleophilic substitution reaction.2. The nitrogen atom in ammonia acts as a nucleophile and attacks the electrophilic carbon atom in benzyl chloride, which is connected to the chlorine atom.3. The chlorine atom leaves as a chloride ion  Cl- , and the nitrogen atom forms a bond with the carbon atom, resulting in the formation of benzylamine  C6H5CH2NH2  and a chloride ion  Cl- .Step 2: Formation of Phenylacetonitrile1. Benzylamine  C6H5CH2NH2  reacts with cyanogen bromide  BrCN  in a nucleophilic substitution reaction.2. The nitrogen atom in benzylamine acts as a nucleophile and attacks the electrophilic carbon atom in cyanogen bromide, which is connected to the bromine atom.3. The bromine atom leaves as a bromide ion  Br- , and the nitrogen atom forms a bond with the carbon atom, resulting in the formation of phenylacetonitrile  C6H5CH2CN  and a bromide ion  Br- .Step 3: Hydrolysis of Phenylacetonitrile to Phenylalanine1. Phenylacetonitrile  C6H5CH2CN  undergoes hydrolysis in the presence of a strong acid  e.g., HCl  and water  H2O .2. The nitrile group  CN  is hydrolyzed to a carboxylic acid group  COOH  by the addition of water and a proton from the acid.3. The resulting compound is phenylalanine  C6H5CH2CH NH2 COOH .In summary, the synthesis of phenylalanine from benzyl chloride and ammonia involves the formation of benzylamine, followed by the reaction with cyanogen bromide to form phenylacetonitrile, and finally, hydrolysis of phenylacetonitrile to obtain phenylalanine.

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