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What is the step-by-step reaction mechanism for the synthesis of ibuprofen from 2-methylpropylbenzene and carbon dioxide?

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The synthesis of ibuprofen from 2-methylpropylbenzene  isobutylbenzene  and carbon dioxide can be achieved through a series of reactions. Here is a step-by-step reaction mechanism:1. Friedel-Crafts Alkylation:First, we need to introduce a carbonyl group to the isobutylbenzene. This can be done through Friedel-Crafts acylation, using acetyl chloride  CH3COCl  and aluminum chloride  AlCl3  as a catalyst.- Isobutylbenzene + CH3COCl  in the presence of AlCl3   2- 4-isobutylphenyl propanoyl chloride2. Hydrolysis:Next, we need to convert the acyl chloride to a carboxylic acid. This can be done through hydrolysis.- 2- 4-isobutylphenyl propanoyl chloride + H2O  2- 4-isobutylphenyl propanoic acid3. Kolbe-Schmitt Reaction:Now, we need to introduce a second carboxylic acid group to the molecule using the Kolbe-Schmitt reaction. This involves treating the 2- 4-isobutylphenyl propanoic acid with carbon dioxide  CO2  and a strong base like sodium hydroxide  NaOH  under high pressure and temperature.- 2- 4-isobutylphenyl propanoic acid + CO2 + NaOH  sodium 2- 4-isobutylphenyl -propionate + H2O4. Acidification:Finally, we need to convert the sodium salt of the carboxylic acid back to the free carboxylic acid, which is ibuprofen. This can be done by acidification using a strong acid like hydrochloric acid  HCl .- Sodium 2- 4-isobutylphenyl -propionate + HCl  ibuprofen  2- 4-isobutylphenyl propionic acid  + NaClIn summary, the synthesis of ibuprofen from 2-methylpropylbenzene and carbon dioxide involves Friedel-Crafts acylation, hydrolysis, Kolbe-Schmitt reaction, and acidification.
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