The most suitable polymer-based biomaterial for developing a tissue-engineered scaffold for articular cartilage repair is a combination of natural and synthetic polymers, such as chitosan, hyaluronic acid, and poly lactic-co-glycolic acid PLGA .Chitosan is a natural polymer derived from chitin, which is found in the exoskeleton of crustaceans. It is biocompatible, biodegradable, and has good mechanical properties. Chitosan also has the ability to promote cell adhesion and proliferation, making it an ideal choice for cartilage repair.Hyaluronic acid is another natural polymer that is a major component of the extracellular matrix in cartilage. It has excellent biocompatibility, water retention capacity, and viscoelastic properties. Incorporating hyaluronic acid into the scaffold can help mimic the native cartilage environment and promote chondrocyte function.Poly lactic-co-glycolic acid PLGA is a synthetic, biodegradable polymer that has been widely used in tissue engineering applications due to its tunable mechanical properties, degradation rate, and biocompatibility. PLGA can provide structural support to the scaffold and can be tailored to match the mechanical properties of native cartilage.By combining these polymers, a composite scaffold can be developed that possesses the desired properties for articular cartilage repair, such as biocompatibility, biodegradability, mechanical strength, and the ability to promote chondrocyte adhesion, proliferation, and differentiation. This composite scaffold can provide an optimal environment for cartilage regeneration and repair.