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What is the most efficient method for synthesizing a carboxylic acid from an alkyl halide? Provide a detailed mechanism, including all reagents and reaction conditions involved.

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The most efficient method for synthesizing a carboxylic acid from an alkyl halide is through a two-step process: first, the nucleophilic substitution of the alkyl halide with a cyanide ion  CN-  to form a nitrile, followed by hydrolysis of the nitrile to form the carboxylic acid. Here is a detailed mechanism, including all reagents and reaction conditions involved:Step 1: Nucleophilic substitution of the alkyl halide with a cyanide ionReagents: Sodium cyanide  NaCN  or potassium cyanide  KCN Solvent: Dimethyl sulfoxide  DMSO  or another polar aprotic solventReaction conditions: Room temperature or slightly elevated temperature  50-60C , under an inert atmosphere  e.g., nitrogen or argon Mechanism:1. The cyanide ion  CN-  acts as a nucleophile and attacks the electrophilic carbon atom of the alkyl halide  R-X, where R is an alkyl group and X is a halogen .2. The bond between the carbon and the halogen breaks, with the halogen leaving as a halide ion  X- .3. The nitrile  R-CN  is formed as the product.Step 2: Hydrolysis of the nitrile to form the carboxylic acidReagents: Aqueous acid  e.g., H2SO4, HCl  or base  e.g., NaOH, KOH Solvent: WaterReaction conditions: Reflux  heating under continuous condensation  at 100-110C for several hoursMechanism  under acidic conditions :1. The carbonyl carbon of the nitrile  R-CN  is protonated by the acid  H+ , forming an iminium ion  R-CNH+ .2. A water molecule attacks the electrophilic carbonyl carbon, forming a tetrahedral intermediate.3. The iminium ion is deprotonated, resulting in the formation of an amide  R-CONH2 .4. The amide nitrogen is protonated by the acid  H+ , forming a protonated amide  R-CONH3+ .5. A water molecule attacks the electrophilic carbonyl carbon, forming a second tetrahedral intermediate.6. The tetrahedral intermediate collapses, releasing a water molecule and forming a protonated carboxylic acid  R-COOH2+ .7. The protonated carboxylic acid is deprotonated, yielding the final carboxylic acid product  R-COOH .Mechanism  under basic conditions :1. The cyanide ion  CN-  is attacked by a hydroxide ion  OH- , forming a metal cyanate intermediate  R-CNO- .2. The metal cyanate intermediate rearranges to form an amide  R-CONH2 .3. The amide is attacked by a hydroxide ion  OH- , forming a tetrahedral intermediate.4. The tetrahedral intermediate collapses, releasing an amine  NH2-  and forming a carboxylate ion  R-COO- .5. The carboxylate ion is protonated by water, yielding the final carboxylic acid product  R-COOH .In summary, the most efficient method for synthesizing a carboxylic acid from an alkyl halide involves a two-step process: nucleophilic substitution with a cyanide ion to form a nitrile, followed by hydrolysis of the nitrile to form the carboxylic acid.

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