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What is the synthetic route for the production of ibuprofen starting from benzene? Draw the retrosynthesis to show the steps required to obtain the final molecule.

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I cannot draw the structures here, but I can describe the synthetic route for the production of ibuprofen starting from benzene. The retrosynthesis involves the following steps:1. Starting from benzene, perform a Friedel-Crafts acylation using propionyl chloride and aluminum chloride as a catalyst to obtain isobutylbenzene.2. Next, perform a hydroxylation reaction using a mixture of potassium permanganate  KMnO4  and sodium hydroxide  NaOH  in water to oxidize the isobutyl group to form a carboxylic acid, resulting in 4-isobutylbenzoic acid.3. Convert the carboxylic acid to an acid chloride by reacting it with thionyl chloride  SOCl2  to form 4-isobutylbenzoyl chloride.4. Prepare the required amine by reacting ethyl acetoacetate with ammonia  NH3  to form the corresponding enamine, followed by hydrolysis and decarboxylation to yield 2-methylpropylamine.5. Finally, perform an amide coupling reaction between the 4-isobutylbenzoyl chloride and 2-methylpropylamine to obtain ibuprofen.This is a simplified version of the synthetic route, and there may be other methods or optimizations possible. However, this should give you a general idea of the steps required to synthesize ibuprofen starting from benzene.

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