To develop more effective treatments for skin diseases like eczema or psoriasis, the properties of different compounds can be manipulated in several ways. These include:1. Enhancing penetration and absorption: The effectiveness of a treatment depends on its ability to penetrate the skin and reach the target site. By modifying the molecular size, lipophilicity, or by using penetration enhancers, the absorption of the compound can be improved, allowing it to reach the affected area more efficiently.2. Targeted delivery: Developing compounds that specifically target the cells or pathways involved in the disease can help minimize side effects and increase the effectiveness of the treatment. This can be achieved by attaching the active compound to a carrier molecule that selectively binds to the target site or by designing compounds that only become active once they reach the target site.3. Controlled release: By incorporating the active compound into a controlled-release system, such as microspheres, liposomes, or hydrogels, the drug can be released slowly and steadily over time. This can help maintain a consistent concentration of the drug at the target site, reducing the need for frequent application and improving patient compliance.4. Reducing irritation: Some compounds may cause irritation or other side effects when applied to the skin. By modifying the chemical structure of the compound or by combining it with other ingredients that have soothing or anti-inflammatory properties, the potential for irritation can be minimized.5. Synergistic effects: Combining two or more compounds with complementary mechanisms of action can result in a synergistic effect, where the combined effect is greater than the sum of the individual effects. This can lead to more effective treatments with lower doses of each compound, reducing the risk of side effects.6. Stability and shelf life: The stability of a compound can affect its effectiveness over time. By modifying the chemical structure or incorporating stabilizing agents, the shelf life of the treatment can be extended, ensuring that it remains effective for a longer period.7. Patient compliance: The ease of use and cosmetic acceptability of a treatment can influence patient compliance. By developing formulations that are easy to apply, have a pleasant texture and appearance, and do not cause staining or other undesirable effects, patients may be more likely to use the treatment as directed.In summary, by manipulating the properties of different compounds and considering factors such as penetration, targeted delivery, controlled release, reduced irritation, synergistic effects, stability, and patient compliance, more effective treatments for skin diseases like eczema and psoriasis can be developed.