A novel drug delivery system for an anti-cancer drug with low bioavailability and improved efficacy could be designed using a combination of nanoparticle-based carriers, prodrug strategies, and targeted delivery approaches. This system would address the challenges associated with the drug's poor solubility, low permeability, and non-specific distribution, ultimately enhancing its therapeutic potential.1. Nanoparticle-based carriers: Encapsulating the anti-cancer drug within biocompatible and biodegradable nanoparticles can improve its solubility and stability. Examples of nanoparticle carriers include liposomes, polymeric nanoparticles, and micelles. These carriers can protect the drug from degradation, prolong its circulation time, and facilitate its transport across biological barriers, thereby enhancing its bioavailability.2. Prodrug strategies: Converting the anti-cancer drug into a prodrug can improve its physicochemical properties and pharmacokinetic profile. A prodrug is an inactive derivative of the parent drug that undergoes enzymatic or chemical transformation in the body to release the active drug. By modifying the drug's structure, it is possible to increase its solubility, permeability, and stability, as well as reduce its toxicity and side effects.3. Targeted delivery approaches: Conjugating the anti-cancer drug or its nanoparticle carrier with targeting ligands, such as antibodies, peptides, or small molecules, can enable selective delivery to cancer cells. This targeted approach can minimize the drug's non-specific distribution and off-target effects, thereby improving its therapeutic index. Additionally, stimuli-responsive drug delivery systems can be designed to release the drug in response to specific triggers, such as changes in pH, temperature, or enzyme activity, which are characteristic of the tumor microenvironment.In conclusion, a novel drug delivery system for an anti-cancer drug with low bioavailability can be designed by combining nanoparticle-based carriers, prodrug strategies, and targeted delivery approaches. This multifaceted approach can address the challenges associated with the drug's poor solubility, low permeability, and non-specific distribution, ultimately enhancing its therapeutic potential and improving patient outcomes.