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How do changes in metabolite levels affect the overall function of a biological system, and can these changes be used to predict or diagnose diseases?
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BioChemistry
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How do changes in membrane structure affect the permeability and selectivity of a biological membrane, and what is the role of membrane proteins in modulating these properties?
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How do changes in lipid metabolism affect cellular signaling pathways? Provide detailed examples of specific lipids involved in signaling and metabolism, and explain their physiological roles in various cellular processes.
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How do changes in lipid metabolism and transport impact the risk of cardiovascular disease?
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How do changes in the ligand structure affect the electronic and magnetic properties of transition metal complexes and how can these changes be predicted using computational methods in quantum chemistry?
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How do changes in environmental pH affect the catalytic activity of enzymes?
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How do changes in environmental conditions affect the metabolic pathways and molecular networks involved in cellular metabolism? Provide examples using metabolomics and systems biology approaches.
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How do changes in atmospheric concentrations of greenhouse gases contribute to global warming and what chemical reactions are involved in their formation and breakdown?
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Environmental Chemistry
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How can changes in atmospheric concentrations of greenhouse gases impact global temperatures and what chemical reactions take place to contribute to this effect?
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Environmental Chemistry
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Can you propose a suitable reaction mechanism for the preparation of 2,4-dinitrophenol from phenol and nitric acid, and explain the key reaction steps and intermediates involved?
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How do certain drugs interact with each other in the human body, and what is the impact of these interactions on drug efficacy and potential side effects?
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Medicinal Chemistry
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How do certain chemical modifications in precursor RNA molecules affect splice site selection and ultimately impact the final mRNA isoforms produced during RNA processing?
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How do certain amino acid sequences affect the folding mechanism of proteins, as observed through molecular dynamics simulations, and how can this information be used to understand and design more effective protein therapeutics?
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Computational Chemistry
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How does the accumulation of ceramides contribute to insulin resistance and Type 2 Diabetes Mellitus in lipid metabolism?
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BioChemistry
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What are the specific properties of ceramics that make them suitable for use in high-temperature applications, and how can these properties be manipulated to improve their performance in extreme environments?
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Materials Chemistry
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What are the key material properties that make ceramics suitable for high-temperature applications, and how can these properties be optimized or improved through chemical and material design?
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Materials Chemistry
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What are the key properties and structural characteristics that make ceramics suitable for high-temperature applications, and how do these properties compare to those of other materials used at high temperatures?
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Materials Chemistry
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How do the properties of ceramics change at high temperatures, and what makes them suitable for use in high-temperature applications such as gas turbine engines and furnace linings?
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Jan 31
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Materials Chemistry
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How do cells recognize and selectively degrade specific proteins within the cell? Describe the molecular mechanisms that underlie protein degradation and the various pathways involved.
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Jan 31
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BioChemistry
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What are the lipid components of cell membranes and how do they contribute to the membrane's structure and function?
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