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Due to the __________ nature of the lipids that make up cell membranes, polar molecules (such as water) and ions cannot easily diffuse across the cell membrane.

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hydrophobic

Small nonpolar molecules can easily diffuse across the cell membrane. However, due to the hydrophobic nature of the lipids that make up cell membranes, polar molecules  such as water  and ions cannot do so. Instead, they diffuse across the membrane through transport proteins. A transport protein completely spans the membrane, and allows certain molecules or ions to diffuse across the membrane. Channel proteins, gated channel proteins, and carrier proteins are three types of transport proteins that are involved in facilitated diffusion.

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