immune
Chapter 42 1 Figure 42.11 C 3 Figure 42.16 If the blood of the mother and fetus mixes, memory cells that recognize the Rh antigen can form late in the first pregnancy. During subsequent pregnancies, these memory cells launch an immune attack on the fetal blood cells. Injection of anti-Rh antibody during the first pregnancy prevents the immune response from occurring. 4 D 6 A 8 D 10 B 12 D 14 C 16 C 18 D 20 C 22 If the MHC I molecules expressed on donor cells differ from the MHC I molecules expressed on recipient cells, NK cells may identify the donor cells as non-self and produce perforin and granzymes to induce the donor cells to undergo apoptosis, which would destroy the transplanted organ. 24 An antigen is a molecule that reacts with some component of the immune response antibody, B cell receptor, T cell receptor . An epitope is the region on the antigen through which binding with the immune component actually occurs. 26 The TH1 response involves the secretion of cytokines to stimulate macrophages and CTLs and improve their destruction of intracellular pathogens and tumor cells. It is associated with inflammation. The TH2 response is involved in the stimulation of B cells into plasma cells that synthesize and secrete antibodies. 28 T cells bind antigens that have been digested and embedded in MHC molecules by APCs. In contrast, B cells function themselves as APCs to bind intact, unprocessed antigens. 30 Cross reactivity of antibodies can be beneficial when it allows an individual's immune system to respond to an array of similar pathogens after being exposed to just one of them. A potential cost of cross reactivity is an antibody response to parts of the body self in addition to the appropriate antigen.