osmolality
Regulation of Water Intake Osmolality is the ratio of solutes in a solution to a volume of solvent in a solution. Plasma osmolality is thus the ratio of solutes to water in blood plasma. A persons plasma osmolality value reflects his or her state of hydration. A healthy body maintains plasma osmolality within a narrow range, by employing several mechanisms that regulate both water intake and output. Drinking water is considered voluntary. So how is water intake regulated by the body? Consider someone who is experiencing dehydration, a net loss of water that results in insufficient water in blood and other tissues. The water that leaves the body, as exhaled air, sweat, or urine, is ultimately extracted from blood plasma. As the blood becomes more concentrated, the thirst responsea sequence of physiological processesis triggered Figure 26.10 . Osmoreceptors are sensory receptors in the thirst center in the hypothalamus that monitor the concentration of solutes osmolality of the blood. If blood osmolality increases above its ideal value, the hypothalamus transmits signals that result in a conscious awareness of thirst. The person should and normally does respond by drinking water. The hypothalamus of a dehydrated person also releases antidiuretic hormone ADH through the posterior pituitary gland. ADH signals the kidneys to recover water from urine, effectively diluting the blood plasma. To conserve water, the hypothalamus of a dehydrated person also sends signals via the sympathetic nervous system to the salivary glands in the mouth. The signals result in a decrease in watery, serous output and an increase in stickier, thicker mucus output . These changes in secretions result in a dry mouth and the sensation of thirst.