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What important organelle (that would otherwise be centrally located and crucial to the cell's survival) do prokaryotic cells lack?

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nucleus

Cell division is simpler in prokaryotes than eukaryotes because prokaryotic cells themselves are simpler. Prokaryotic cells have a single circular chromosome, no nucleus, and few other organelles. Eukaryotic cells, in contrast, have multiple chromosomes contained within a nucleus, and many other organelles. All of these cell parts must be duplicated and then separated when the cell divides. A chromosome is a molecule of DNA, and will be the focus of a subsequent concept.

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