uterine tube
Contact Between Sperm and Oocyte Upon ovulation, the oocyte released by the ovary is swept intoand alongthe uterine tube. Fertilization must occur in the distal uterine tube because an unfertilized oocyte cannot survive the 72-hour journey to the uterus. As you will recall from your study of the oogenesis, this oocyte specifically a secondary oocyte is surrounded by two protective layers. The corona radiata is an outer layer of follicular granulosa cells that form around a developing oocyte in the ovary and remain with it upon ovulation. The underlying zona pellucida pellucid = transparent is a transparent, but thick, glycoprotein membrane that surrounds the cells plasma membrane. As it is swept along the distal uterine tube, the oocyte encounters the surviving capacitated sperm, which stream toward it in response to chemical attractants released by the cells of the corona radiata. To reach the oocyte itself, the sperm must penetrate the two protective layers. The sperm first burrow through the cells of the corona radiata. Then, upon contact with the zona pellucida, the sperm bind to receptors in the zona pellucida. This initiates a process called the acrosomal reaction in which the enzyme-filled cap of the sperm, called the acrosome, releases its stored digestive enzymes. These enzymes clear a path through the zona pellucida that allows sperm to reach the oocyte. Finally, a single sperm makes contact with sperm-binding receptors on the oocytes plasma membrane Figure 28.2 . The plasma membrane of that sperm then fuses with the oocytes plasma membrane, and the head and mid-piece of the winning sperm enter the oocyte interior. How do sperm penetrate the corona radiata? Some sperm undergo a spontaneous acrosomal reaction, which is an acrosomal reaction not triggered by contact with the zona pellucida. The digestive enzymes released by this reaction digest the extracellular matrix of the corona radiata. As you can see, the first sperm to reach the oocyte is never the one to fertilize it. Rather, hundreds of sperm cells must undergo the acrosomal reaction, each helping to degrade the corona radiata and.