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How do genetic variations affect the response of different individuals to the same drug and how can medicinal chemists use this information to design personalized treatments?

asked Feb 13 in Medicinal Chemistry by Precious09K0 (2.8k points)

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How do genetic variations affect the metabolism and effectiveness of drugs used in the treatment of diabetes, and what are the implications of this for personalized medicine?

asked Feb 13 in Medicinal Chemistry by LizaSwenson (2.2k points)

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How do genetic variations affect drug response in patients with specific diseases such as cardiovascular diseases or cancer?

asked Feb 13 in Medicinal Chemistry by AntoniettaLa (2.7k points)

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How does genetic variation influence the metabolism and efficacy of anti-cancer drugs in different patient populations?

asked Feb 13 in Medicinal Chemistry by CandelariaFe (2.3k points)

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How does genetic variation influence drug response and efficacy in patients with cancer? Specifically, investigate the relationship between genetic markers and the response to chemotherapy drugs used in cancer treatment.

asked Feb 13 in Medicinal Chemistry by MargieJobson (2.1k points)

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What are the effects of genetic variation on drug response in the treatment of breast cancer, and how can medicinal chemists develop personalized therapies based on pharmacogenetic data?

asked Feb 13 in Medicinal Chemistry by SergioCrews1 (2.7k points)

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How does genetic variation affect the metabolism and effectiveness of clopidogrel, a commonly used antiplatelet drug, and what are the implications for personalized medicine?

asked Feb 13 in Medicinal Chemistry by RemonaPinto (2.3k points)

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How does genetic variability affect the metabolization and efficacy of anti-cancer drugs in patients with different CYP2D6 genotypes?

asked Feb 13 in Medicinal Chemistry by MoniqueBrins (2.1k points)

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How does genetic variability influence drug response and efficacy in the treatment of cancer patients, specifically for the chemotherapy drug cisplatin?

asked Feb 13 in Medicinal Chemistry by SvenJonathan (2.2k points)

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What are the advantages and limitations of using gel permeation chromatography for the characterization of a polymer sample?

asked Feb 13 in Polymer Chemistry by Patsy0696347 (1.9k points)

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How can we determine the molecular weight distribution of a polymer using gel permeation chromatography (GPC)?

asked Feb 13 in Polymer Chemistry by AgnesXyg5256 (2.3k points)

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How can we use gel permeation chromatography (GPC) to determine the molecular weight distribution of a polymer sample?

asked Feb 13 in Polymer Chemistry by EloisaLeavit (2.3k points)

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How can we quantitatively determine the molecular weight distribution of a polymer using gel permeation chromatography (GPC) and what are the important parameters to optimize for accurate results?

asked Feb 13 in Polymer Chemistry by RemonaPinto (2.3k points)

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What are the differences between gel permeation chromatography and size exclusion chromatography, and how can these techniques be used to characterize polymers with different molecular weights and distributions?

asked Feb 13 in Polymer Chemistry by OctavioCarva (2.3k points)

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What is the structure and bonding of the metal complexes in gadolinium-based metallofullerenes, and how do they affect the magnetic properties of the compound?

asked Feb 13 in Coordination Chemistry by KristopherMi (2.3k points)

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How does the activation of G protein-coupled receptors (GPCRs) lead to the activation of downstream signal transduction pathways in biochemical terms?

asked Feb 13 in BioChemistry by JoycelynFran (2.2k points)

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How do G protein-coupled receptors (GPCRs) initiate signal transduction pathways in cells and how can their activity be modulated by different allosteric ligands?

asked Feb 13 in BioChemistry by RobertoMundy (2.0k points)

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1 answer 10 views

How do G protein-coupled receptors (GPCRs) initiate signal transduction pathways in cells? Discuss the biochemical mechanism involved in the activation of GPCRs and the downstream signaling events that follow.

asked Feb 13 in BioChemistry by VictorGanz19 (2.4k points)

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How does the activation of G protein-coupled receptors (GPCRs) initiate signal transduction pathways in biochemistry, and what is the specific biochemical mechanism involved in this process?

asked Feb 13 in BioChemistry by OctaviaAbe18 (2.2k points)

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What is the structural difference between furan and pyrrole, and what effect does this structural difference have on their chemical reactivity and physical properties? Provide specific examples of reactions and properties to support your answer.

asked Feb 13 in Organic Chemistry by Ashleigh66X2 (2.6k points)

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