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What is the specific coordination geometry of the metal center in the active site of the metalloenzyme myoglobin, and what is the significance of this geometry in the enzyme's function?
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What is the coordination geometry of the metal center in the active site of the metalloenzyme carbonic anhydrase, and how does it contribute to the enzyme's function?
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Coordination Chemistry
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What is the coordination geometry and number of the metal center in the active site of hemoglobin?
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What is the coordination geometry and number of the metal center in hemoglobin and myoglobin? How does this affect the binding and transport of oxygen in these metalloproteins?
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How does the metabolome of a cancer cell differ from that of a healthy cell, and how can this information be used to develop new cancer treatments?
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How does the metabolite profile of cancer cells differ from normal cells, and how can this information be used in the development of new cancer treatments using systems biology approaches?
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How does the metabolism of lipids affect the signaling pathways involved in insulin resistance, and how can this understanding be used in the development of new drugs for the treatment of diabetes?
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How does the metabolism of lipids affect cell signalling pathways in the body? Provide an in-depth explanation of the biochemical processes involved and any relevant examples.
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How does the metabolism of drugs in the body affect their efficacy and toxicity in treating specific diseases?
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How does the metabolism of drugs in the body affect their efficacy and potential adverse effects? Provide specific examples of some drugs and their metabolites, and explain the role of enzymes and pathways involved in drug metabolism.
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How does the metabolism of different types of lipids, such as phospholipids, triacylglycerols and sphingolipids, differ in the process of lipid signaling and how does it affect cell membrane structure and function?
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How does the metabolic state of cancer cells differ from that of normal cells, and how can metabolomics and systems biology be used to develop targeted therapies for cancer treatment?
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BioChemistry
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How does the metabolic state of a cell change in response to different environmental stressors such as nutrient depletion, oxidative stress, and exposure to toxins, and how can this be studied using metabolomics and systems biology approaches?
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How does the metabolic profile of cancer cells differ from that of normal cells, and what implications does this have for understanding the underlying molecular mechanisms and developing targeted therapies?
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How does the metabolic profile of cancer cells differ from that of normal cells, and how can this information be used to develop targeted therapies to treat cancer?
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How does the metabolic profile of cancer cells differ from normal cells, and how can this knowledge be applied in developing new cancer treatments?
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How does the metabolic profile of cancer cells differ from that of normal cells, and how can this information be used to develop targeted cancer therapies?
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How does the metabolic profile of cancer cells differ from that of healthy cells, and how can this information be used to develop targeted cancer treatments?
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How does the metabolic profile of cancer cells differ from healthy cells, and what are the key metabolic pathways and enzymes that contribute to these differences?
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How does the metabolic profile of cancer cells differ from normal cells, and how can this information be used to develop targeted therapies for cancer?
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